Gastrointestinal toxicity of minor analgesics.
نویسندگان
چکیده
منابع مشابه
Gastrointestinal Toxicity of Irinotecan
Clinical observations, preclinical models, and pharmacokinetic studies have yielded some critical insights into the pathophysiology of these side effects. Early recognition and treatment of these toxicities have resulted in a reduction in patient morbidity. Despite these new pathophysiologic insights and advances in treatment, gastrointestinal toxicities remain a major problem with the clinical...
متن کامل[Toxicity of analgesics in the family doctor practice].
Analgesic usage without any consultation with a physician is very common in Poland. It increases the risk of occurrence of the harmful effect or harmful interaction with other medicaments taken by the patient. The abuse of painkillers applies not only to opioid but also to nonopioid analgesics. The largest group of commonly available medicaments are NSAIDs. The most frequent undesirable effect ...
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It is estimated that at least 50 million people in the United States suff er from chronic pain conditions while an additional 25 million people suff er from acute pain [1]. Pain aff ects patient quality of life and is a major reason for healthcare utilization [2], accounting for 20% of outpatient visits and 12% of all prescriptions [3]. Nonsteroidal anti-infl ammatory drugs (NSAIDs) remain a ma...
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Toxicity resulting from excessive intra-synaptic serotonin, historically referred to as serotonin syndrome, is now understood to be an intra-synaptic serotonin concentration-related phenomenon. Recent research more clearly delineates serotonin toxicity as a discreet toxidrome characterized by clonus, hyper-reflexia, hyperthermia and agitation. Serotonergic side-effects occur with serotonergic d...
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PURPOSE OF REVIEW The present review is timely owing to the previous paucity of biomarkers, particularly functional noninvasive tests, to evaluate the extent and severity of gastrointestinal toxicity in both animal models of chemotherapy and in cancer patients undergoing chemotherapy. RECENT FINDINGS The most recent findings using noninvasive functional biomarkers now allow longitudinal monit...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1980
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.1980.tb01831.x